Low Sensitivity

1

Partial blockage in nebulizer or nebulizer inlet tube

Pump a 50/50 water/acetone mixture into ELSD at highest flow rate possible (do not exceed 5 mL/min) for 16 h.

2

Internal solvent trap is empty

Fill the front solvent trap with liquid until any excess flows out through front drain tube.

3

Gas pressure too low

Ensure inlet gas pressure >60 psi.

4

Laser power

Verify by switching the unit from STANDBY to RUN and check offset.

5

Optical chamber is contaminated

Clean contamination from widows in optical chamber.

6

Diffuser saturated with solvent

Stop the eluent flow and increase the evaporator temperature to maximum. Increase the flow rate to 2.8 SLM and wait 1 h.