When a solvent is metered at ambient pressure and compressed to a higher pressure, the volume decreases depending on its compressibility. Solvent compressibility is a non-linear function of pressure and temperature. It is specific for each solvent.
In order to deliver the desired flow accurately at all pressures, Agilent pumps use a compressibility compensation. For standard LC applications, e.g. using a 400 bar binary pump, an average compressibility value for the solvent is sufficient.
For the 600 bar 1260 Infinity III Binary Pump, the pressure-dependency of a solvent compressibility needs to be considered. It is determined at different pressures between 0 – 600 bar. The pump uses the obtained non-linear function to select the correct compressibility value for the actual pump pressure. Compressibility data for the most common solvents is readily available in the pump firmware.
The compensation algorithm is so powerful that the damper and mixer can be removed from the pump flow path at low flow rate while the pressure ripple and composition ripple remain at low levels.
For method compatibility reasons, the legacy compressibility compensation is still available.
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