Replacing the sample solvent with a much less polar solvent can allow injection of much larger volumes. However, the new solvent must be significantly less polar than the modifier used. Replacing methanol with ethanol or even isopropanol has minimal effect. Solvents such as chloroform or methylene chloride tend to cause significant focusing (NO broadening), but since they are chlorinated should probably be avoided.
base-id: 4540204811
id: 4540204811