Any solvent that is intended for use with the ELS Detector should be thoroughly degassed, filtered (0.45 µm) and fully compatible with the columns. Solvents that are not properly degassed may cause problems at nebulization leading to a poor reproducibility.
Nonvolatile buffers are not compatible with the ELS Detector and should not be used. Only volatile mobile phase additives, such as those listed in Volatile mobile additives compatible with ELS detection should be used with the ELS detector.
Tetrahydrofuran (THF) stabilized with BHT, may increase the baseline noise level. Where possible unstabilized THF should be used with the ELS detector.
Solvents with high boiling points such as N-methylpyrrolidone (NMP), Dimethylsulphoxide (DMSO), m-Cresol, and 1,2,4-Trichlorobenzene (TCB) are not recommended.
base-id: 4344638475
id: 4344638475