The compressibility of the mobile phase has an effect on the performance of the pump. For best flow accuracy and mixing performance, the compressibility parameter in the Method Settings of the pump shall be chosen according to the mobile phase being used. This method setting activates the algorithm associated with the Agilent Solvent Calibration Tables.
If your solvent is neither available in the user interface nor in the library, please use generic solvents. "Generic aqueous" gives good results for most solvent mixtures with at least 50 % water, which have similar properties as pure water. For other solvents with high organic percentage, "Generic organic" gives a good approximation.
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