A degasser removes air, which is dissolved in any solvent. When solvents are heated or mixed with other solvents, air can leave the solvent and form small bubbles. Over time, these bubbles accumulate and can cause pressure fluctuations which may finally result in retention time shifts.
All Agilent 1200 Infinity II/III Series Pumps have a built-in degasser. While a degasser is needed for low pressure mixing pumps like Agilent quaternary pumps, high pressure mixing pumps like Agilent binary pumps are more robust with respect to bubble formation. However, a degasser is recommended for best performance.
Additionally, a degasser is highly recommended for the following applications:
Your detector is used with maximum sensitivity in the low UV wavelength range.
Your application requires highest injection precision.
Your application requires highest retention-time reproducibility (flow rates below 0.5 mL/min).
The binary pump is used with bypassed damper and mixer.
The external G7122A Degasser is recommended for use with applications using highly volatile solvents like Hexane or DCM, solvents with special characteristics like THF, or applications using refractive index detection.
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