Your normal LC grade solvents usually give good results most of the time. But experience shows that baseline noise can be higher (lower signal-to-noise ratio) when impurities are in the solvents.
Flush your solvent delivery system for at least 15 minutes before checking sensitivity. If your pump has multiple channels, you should also flush the channels not in use.
For optimal results refer to Optimizing the Performance of the G7123B Fluorescence Detector.
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id: 13911566603